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Total 20786 results found since Jan 2013.

Derivation and validation of a search algorithm to retrospectively identify CRRT initiation in the...
Conclusions: The use of an electronic search strategy resulted in determining an accurate CRRT initiation time among ECMO patients....
Source: Applied Clinical Informatics - June 29, 2016 Category: Information Technology Source Type: research

High-performance information search filters for acute kidney injury content in PubMed, Ovid Medline and Embase
Conclusions PubMed, Ovid Medline and Embase can be filtered for articles relevant to AKI in a reliable manner. These high-performance information filters are now available online and can be used to better identify AKI content in large bibliographic databases.
Source: Nephrology Dialysis Transplantation - March 27, 2014 Category: Urology & Nephrology Authors: Hildebrand, A. M., Iansavichus, A. V., Haynes, R. B., Wilczynski, N. L., Mehta, R. L., Parikh, C. R., Garg, A. X. Tags: Acute Kidney Injury Source Type: research

Kidney and liver organ transplantation in persons with human immunodeficiency virus: An Evidence-Based Analysis.
The objective of this analysis is to determine the effectiveness of solid organ transplantation in persons with end stage organ failure (ESOF) and human immunodeficiency virus (HIV+) CLINICAL NEED: CONDITION AND TARGET POPULATION Patients with end stage organ failure who have been unresponsive to other forms of treatment eventually require solid organ transplantation. Similar to persons who are HIV negative (HIV-), persons living with HIV infection (HIV+) are at risk for ESOF from viral (e.g. hepatitis B and C) and non-viral aetiologies (e.g. coronary artery disease, diabetes, hepatocellular carcinoma). Additionally, H...
Source: Ontario Health Technology Assessment Series - December 20, 2015 Category: Journals (General) Tags: Ont Health Technol Assess Ser Source Type: research

Newest strategies in the search for bioactive saponins from the tropical plant biodiversity.
Abstract This review will focus on newest results leading to the discovery of new bioactive saponins by using a combination of successive advanced procedures in extraction, isolation, structure elucidation and bioassays. Microwave- and ultrasonic-assisted extractions, two recent advanced methods have been increasingly used in the last decade. Then, a multistep purification procedure was achieved by flash chromatography, vacuum liquid chromatography, low, medium- and high-pressure liquid chromatography on silica gel and reversed-phase silica gel RP-18 (VLC, LPLC, MPLC, HPLC). These successive chromatographic steps ...
Source: Current Drug Delivery - November 1, 2015 Category: Drugs & Pharmacology Authors: Lacaille-Dubois MA Tags: Curr Drug Deliv Source Type: research

Infrapopliteal calcification patterns in critical limb ischemia: diagnostic, pathologic and therapeutic implications in the search for the endovascular holy grail.
This article attempts to review the implications of the diverse pathologic patterns of calcium distribution in infrapopliteal vessels of CLI patients, on the diagnostic modalities, technological developments, and the evolution of therapeutic approaches to improve outcomes among these patients. A critical analysis of the currently available data is provided, pointing to the surprising omission on the role of calcium on outcomes, and future directions are discussed. Is infrapopliteal calcium a roadblock or the avenue towards new paths? Necessity remains the mother of invention. PMID: 28240525 [PubMed - as supplied by publisher]
Source: The Journal of Cardiovascular Surgery - February 26, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Mustapha JA, Diaz-Sandoval LJ, Saab F Tags: J Cardiovasc Surg (Torino) Source Type: research

Beat von Albertini: Lifetime search for increased dialysis treatment efficiency-An obituary.
PMID: 29739308 [PubMed - in process]
Source: The International Journal of Artificial Organs - May 1, 2018 Category: Transplant Surgery Authors: Vienken J, Walpoth B, European Society for Artificial Organs (ESAO) Tags: Int J Artif Organs Source Type: research

Starting Dialysis-Planning for the Unpredictable and the Search for Meaningful Process Measures.
Authors: Wilkie M PMID: 30185476 [PubMed - in process]
Source: Peritoneal Dialysis International - September 7, 2018 Category: Urology & Nephrology Tags: Perit Dial Int Source Type: research

The search for brain-permeant NKCC1 inhibitors for the treatment of seizures: Pharmacokinetic-pharmacodynamic modelling of NKCC1 inhibition by azosemide, torasemide, and bumetanide in mouse brain.
Abstract Because of its potent inhibitory effect on the Na+-K+-2Cl- symporter isotype 1 (NKCC1) in brain neurons, bumetanide has been tested with varying results for treatment of seizures that potentially evolve as a consequence of abnormal NKCC1 activity. However, because of its physicochemical properties, bumetanide only poorly penetrates into the brain. We previously demonstrated that NKCC1 can be also inhibited by azosemide and torasemide, which lack the carboxyl group of bumetanide and thus should be better brain-permeable. Here we studied the brain distribution kinetics of azosemide and torasemide in compari...
Source: Epilepsy and Behaviour - December 2, 2020 Category: Neurology Authors: Hampel P, Römermann K, Gramer M, Löscher W Tags: Epilepsy Behav Source Type: research

Exercise training for adults undergoing maintenance dialysis
CONCLUSIONS: It is uncertain whether exercise training improves death, cardiovascular events, or the mental component of HRQoL in adults undergoing maintenance dialysis. Exercise training probably improves depressive symptoms, particularly when the intervention is maintained beyond four months. Exercise training is also likely to improve functional capacity. Low certainty evidence suggested that exercise training may improve fatigue, the physical component of quality of life, and pain. The safety of exercise training for adults undergoing dialysis remains uncertain.PMID:35018639 | PMC:PMC8752366 | DOI:10.1002/14651858.CD014653
Source: Cochrane Database of Systematic Reviews - January 12, 2022 Category: General Medicine Authors: Amelie Bernier-Jean Nadim A Beruni Nicola P Bondonno Gabrielle Williams Armando Teixeira-Pinto Jonathan C Craig Germaine Wong Source Type: research

A Systematic Review of the Health Impacts of Mass Earth Movements (Landslides)
Conclusions and recommendations We conclude that the health impacts of landslides are poorly documented in almost all respects. Causes of death and the nature of injuries suffered in landslides remain almost entirely undocumented in the literature, and there are very few studies of the nature of treatments required by the victims of landslides. A greater level of information is available with respect to the psychiatric impacts. These studies show that the effects are more substantial than for other types of natural hazards. Probably, this reflects the violence of landslides, but even this evidence is limited. Consequentl...
Source: PLOS Currents Disasters - April 30, 2015 Category: Global & Universal Authors: iaintrk Source Type: research

Pharmacological interventions versus placebo, no treatment or usual care for osteoporosis in people with chronic kidney disease stages 3-5D
CONCLUSIONS: Among patients with CKD stages 3-4, anti-osteoporotic drugs may reduce the risk of vertebral fracture in low certainty evidence. Anti-osteoporotic drugs make little or no difference to the risk of clinical fracture and adverse events in moderate certainty evidence. Among patients with CKD stages 5 and 5D, it is uncertain whether anti-osteoporotic drug reduces the risk of clinical fracture and death because the certainty of this evidence is very low. Anti-osteoporotic drug may slightly improve the BMD at the lumbar spine in low certainty evidence. It is uncertain whether anti-osteoporotic drug improves the BMD ...
Source: Cochrane Database of Systematic Reviews - July 7, 2021 Category: General Medicine Authors: Takashi Hara Yasukazu Hijikata Yukiko Matsubara Norio Watanabe Source Type: research

Experimental Cardiorenal Syndrome Type 3: What Is Known so Far?
CONCLUSION: The findings may explain why AKI increases the risk of acute cardiac complications even if dialysis treatment has been initiated.PMID:35211213 | PMC:PMC8827225 | DOI:10.14740/jocmr4639
Source: Clin Med Res - February 25, 2022 Category: Research Authors: Daniel Patschan Benedikt Marahrens Monique Jansch Susann Patschan Oliver Ritter Source Type: research

Protein restriction for diabetic kidney disease
CONCLUSIONS: Dietary protein restriction has uncertain effects on changes in kidney function over time. However, it may make little difference to the risk of death and kidney failure. Questions remain about protein intake levels and compliance with protein-restricted diets. There are limited data on HRQoL and adverse effects such as nutritional measures and hyperglycaemic events. Large-scale pragmatic RCTs with sufficient follow-up are required for different stages of CKD.PMID:36594428 | PMC:PMC9809923 | DOI:10.1002/14651858.CD014906.pub2
Source: Cochrane Database of Systematic Reviews - January 3, 2023 Category: General Medicine Authors: Shimin Jiang Jinying Fang Wenge Li Source Type: research